Pentobarbital will decrease the level or effect of prednisone by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor. Older adults or those with chronic medical conditions may experience depression, confusion, or excitement after taking the drug. pentobarbital will decrease the level or effect of tinidazole by affecting hepatic/intestinal enzyme CYP3A4 metabolism. https://socials360.com/story10846362/pentobarbital-vs-phenobarbital-una-panoramica