You will find there's release of norepinephrine through the descending inhibitory bulbospinal neurons that binds to alpha-two-receptors inside the dorsal horn to lessen afferent discomfort transmission and deliver analgesia. As a result, drugs like clonidine that focus on alpha-2 receptors can influence the transmission of soreness. Applies to clonidine: https://www.proleviate.com/post/the-new-pain-killer-conolidine