Epidural clonidine used as an adjunct to regional anesthetics has three distinctive mechanisms of action. Initial, the stimulation of alpha-two-receptors within the dorsal horn lessens discomfort transmission. Secondly, clonidine might cause area vasoconstriction that limits vascular elimination of nearby epidural anesthetics. Applies to clonidine: oral tablet, oral tablet extended https://www.proleviate.com/post/the-new-pain-killer-conolidine