Schematic illustration of activated and inhibited Wnt/β-catenin pathway. “WNT ON point out�? Upon ligation of Wnts for their receptors composed of frizzled proteins and LRP5/6, the cytoplasmic protein DVL is activated and induces the suppression of GSK3β. Subsequently, stabilized β-catenin translocates in to the nucleus and binds to TCF/LEF transcription https://dbpr11234567.thechapblog.com/28296600/a-review-of-itd-1