In older people, this is crucial to comprehend as polypharmacy is widespread and can potentiate the chance of DDIs and ADRs. Consequently, concurrent consumption of CYP2D6 inhibitors or inducers could potentiate or block tramadol conversion into ODT and This might boost or minimize efficacy/ADRs on the prescribed tramadol. Literature https://hemalchem.com/product/o-dsmt/